1. On the Tool Bar of Dreamweaver, click Site
2. Select "Define Sites" and Click "New"
3. Use the "Advanced" Tab
Under Local Info Use the following settings:
Site Name: yourdomain.com
Local Folder: This is where you store your web site files on your local PC
HTTP Address: http://yourdomain.com
Enable Cache: check the Dreamweaver documentation to see if you want to enabled this or not.
Under Remote Info
Access: FTP
FTP Host: yourdomain.com
Host Directory: public_html
login: ftp username
password: ftp password
Save: Check the box
Use Passive FTP: checked or unchecked. If you have difficulty retaining your ftp connection, or the connection constantly times out, try toggling this mode to see what works best for you.
Use Firewall: If your Computer is behind a personal firewall, then simply set the configuration. If you do not know what this is, leave it blank.
Enable Checkin/Checkout: Leave this blank unless you understand the implecations of enabling this function.
If you prefer a visual dreamweaver tutorial, use the link.