As promised, here is a simple Dreamweaver tutorial for you.
http://www.glowhost.com/forums/showthread.php?p=417
As for your other questions:
- How to upload my site
Covered in the tutorial
- Do you/I need to delete the current configuration to allow this to work? (meaning what to do with the current files and setup at your company)
You can delete the site and un-install the extensions if you want to have a clean server space, I suggest this method. When I say the site, I do not mean EVERY FILE and FOLDER on the server. It means everything in the public_html folder, with the exception of the cgi-bin. If you do not care, then you can keep the files where they are and just use Dreamweaver to overwrite them as you make your changes to the files. Deleting folders above the public_html level can damage your site, and should be avoided.
- Other important info when using Dreamweaver?
I cannot think of anything, if you have more questions let us know.